I use one hub (harmony elite) to control 2 TVs in different rooms. I placed one of the IR extenders in the 2nd room. The only issue I've found so far is the favourite icons the remote displays only show up for the first watch TV activity. Thus, the 2nd TV has to be controlled using channel numbers. Not a problem if you have a decent memory or them visible somewhere. I can also setup different activities for either TV's. Btw, just use a regular audio extension cable if the IR extender cable is too short.