I literally have thousands of negative keywords organized into about a dozen negative keyword lists. Watch what comes up in your “search terms” for terms that triggered your bids, but clearly weren’t an intended match and add them to negative keywords. With time, you can also add search terms where after many clicks they don’t convert or lots of impressions and a low ctr. For example, I sell board games. So I add negative keywords that reference computer games, but come up in my campaigns (in search terms).