The liver and large intestine are the 2 areas to focus on when trying to "detox". I like teas by Traditional Medicinal and Yogi, they have a bunch of liver detox teas that are gentle and effective. Eating a variety of leafy greens is also very good for your liver. Adding more seeds (flax, chia, sesame) and drinking more water does a pretty good job with the large intestine for most people. It's important to support your liver during weight loss. It's common for people to have to have gallbladder surgery following major weight loss, and it's largely because the liver got overtaxed dealing with byproducts that have been stored in the fat cells.