Are you talking about you going on holiday? Are your campaigns currently doing well and self optimising based on enough data to meet your goal(s)? Are all your ads still relevant while you’re on holiday? Can your business still support orders etc while you’re on holiday? If yes, personally I would keep them running. If you’re having to optimise and change campaigns often, there’s a risk that they could go downhill and your spend is high, or your business cannot support questions, orders etc during that time then I would switch them off.
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