I have PCOS, and a history of early losses. Our first cycle of trying with any type of assistance, we got pregnant “naturally” on our first round of Clomid. However, we ended up losing it, as that turned out to be a partial molar pregnancy. We went on to work with fertility and had a successful first round of IUI with Femara and vaginal progesterone. It was our first round. I didn’t have any really notable side effects, aside from a little cramping, that I can recall. I preferred it to Clomid. Wishing you luck and baby dust!